Imaging applications

Engicare® preclinical imaging activities cover several therapeutic areas: Pharmacology, Oncology, Cardiometabolic diseases, and Nuclear medicine and could be focused on morphological, functional and molecular endpoints.

Area Application Example
Morphology Morphology / anatomy CT – MRI
Pharmacology PK -PD / Biodistribution / bioavailability SPECT – PET after compound radiolabeling
Oncology

Tumor drug targeting 

Tumor volume 

Tumor metabolism 

Tumor proliferation 

Tumor apoptosis 

Necrosis Bone metastases 

SPECT – PET after drug radiolabeling MRI 

18F-FDG

18F-Choline – PET

18F-FLT – PET

99mTc-Annexin V SPECT – MRI

99mTc-HDP SPECT

Cardio-metabolic diseases

Cardiac perfusion 

Cardiac function 

Cardiac metabolism 

Cardiac neurotransmission 

Pulmonary perfusion 

99mTc-Sestamibi / SPECT

99mTc-blood pool / SPECT – MRI

18F-FDG / PET

123I-MIBG / SPECT

99mTc-MAA / SPECT

Nuclear Medicine Imaging biomarker development Clinical radiopharmaceuticals or Customized radiolabeled compounds / SPECT – PET

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