Analytical tools

For each step of bioproduct development, a careful analysis is needed justifying the use of relevant advanced analytical techniques. Indeed, we propose a wide-range of analytical tools allowing to study several parameters such as aggregation and glycosylation profiles, as well as structural properties.

Advanced mass spectroscopy-based methods

(useful for conformational studies and PTM’s)

Surface Plasmon Resonance (SPR) and ellipsometry

(useful for electrostatic interactions studies)

Dynamic Light Scattering (DLS) and turbidimetry

(useful for particle size distribution)

Surface-Enhanced Raman Spectroscopy (SERS)

(useful for conformational studies and PTM’s)

Atomic Force Microscopy (AFM)

(useful for aggregation, conformational and electrostatic interactions studies)

Isoelectric focusing (IEF)

(useful for charge (pI) value determination)

Circular Dichroism Spectroscopy

(useful for aggregation studies)

Protease digestion assay

(useful for aggregation studies)

Size Exclusion Chromatography

(useful for aggregation studies)

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